mouth neoplasms

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	134
interventional	96
Observational	35
Registry	3

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	17
Device	8
Other	7
Procedure	7
Drug|Procedure|Radiation	6
Behavioral	5
Drug|Procedure	5
Drug|Radiation	4
Device|Other	3
Drug|Other	3
Drug|placebo	3
Other|Procedure	3
Biological|Drug	2
Biological|Drug|Other	2
Combination Product	2
Device|Drug|Procedure	2
Drug|Other|placebo	2
Radiation	2
Behavioral|Device|Procedure	1
Behavioral|Other	1
Biological	1
Biological|Other	1
Biological|Other|Radiation	1
Biological|Radiation	1
Device|Drug	1
Diagnostic Test	1
Dietary Supplement	1
Dietary Supplement|Other	1
Drug|Other|Radiation	1
Other|placebo	1
Procedure|Radiation	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	45
China	9
France	7
India	6
Taiwan	6
Canada	4
Brazil	2
Egypt	2
NA	2
Netherlands	2
United Kingdom	2
United States|Canada	2
Denmark	1
Germany	1
Israel	1
Italy	1
Japan	1
Norway	1
United States|Puerto Rico|South Africa	1

Sites per Study

Site_count	Study_Count
1	71
2	5
3	3
4	5
5	1
6	2
7	2
8	2
10	1
35	1
228	1
508	1
789	1

Phase

Phase	Study_Count
N/A	34
Phase 2	21
Phase 1/Phase 2	12
Phase 1	10
Phase 3	7
Early Phase 1	5
Phase 4	4
Phase 2/Phase 3	3

Number of Arms

Number_of_Arms	Count_of_Studies
1	41
2	37
3	5
4	4
5	2
8	1
NA	6

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	8.0	10.0000	3.0	13.00	14.00000	120.0000	62.0000	25.00
1st Qu.	10.0	40.0000	17.0	24.00	33.00000	181.5000	203.5000	28.75
Median	15.0	67.5000	28.0	39.00	64.00000	243.0000	310.0000	150.00
Mean	69.2	158.3235	29.1	43.00	80.90476	295.3333	573.5714	187.50
3rd Qu.	38.0	200.0000	39.0	58.75	101.00000	383.0000	621.5000	308.75
Max.	275.0	1200.0000	57.0	82.00	325.00000	523.0000	1993.0000	425.00

Trial Group Type

group_type	Group_Count
Experimental	110
Active Comparator	22
Other	15
Placebo Comparator	10
No Intervention	7
NA	6

Intervention Model

intervention_model	Study_Count
Parallel Assignment	46
Single Group Assignment	45
Sequential Assignment	3
Crossover Assignment	1
Factorial Assignment	1

Primary Purpose

primary_purpose	Study_Count
Treatment	53
Prevention	15
Diagnostic	12
Supportive Care	6
Health Services Research	4
Screening	3
Basic Science	1
Other	1
NA	1

Observational Studies

Studies by Country

Country	Study_Count
United States	18
Taiwan	6
Egypt	2
NA	2
United Kingdom	2
Belgium	1
Brazil	1
Costa Rica	1
France	1
United States|Colombia|Costa Rica	1

Sites per Study

Site_count	Study_Count
1	31
3	1
5	1
6	1
14	1

Enrollment Metrics

Measure	Observational
Min	10.0000
1st Qu	45.0000
Median	62.5000
Mean	375.0882
3rd Qu	100.0000
Max	8670.0000

Observation Model

observational_model	Study_Count
Cohort	16
Case-Control	7
Case-Only	4
Case Control	3
Other	3
Natural History	1
NA	1

Time Perspective

time_perspective	Study_Count
Prospective	25
Cross-Sectional	3
Retrospective	3
Other	2
Cross-Sectional, Retrospective/Prospective	1
Longitudinal, Prospective	1

Registries

Studies by Country

Country	Study_Count
Canada	1
Sweden	1
United States	1

Sites per Study

Site_count	Study_Count
1	1
2	1
75	1

Enrollment Metrics

Measure	Registries
Min	100.0
1st Qu	230.0
Median	360.0
Mean	333486.3
3rd Qu	500179.5
Max	999999.0

Registry Model

observational_model	Study_Count
Cohort	2
Other	1

Time Perspective

time_perspective	Study_Count
Prospective	3

Follow-up

target_duration	Study_Count
1 Year	1
10 Years	1
80 Years	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT00588770	Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT00588770	Active, not recruiting	National Cancer Institute (NCI)	2018-06-05
NCT03383094	Chemoradiation vs Immunotherapy and Radiation for Head and Neck Cancer	https://ClinicalTrials.gov/show/NCT03383094	Recruiting	University of California, San Diego	2021-04-30
NCT02285530	GDF15 Based TPF Induction Chemotherapy for OSCC Patients	https://ClinicalTrials.gov/show/NCT02285530	Recruiting	Shanghai Jiao Tong University School of Medicine	2022-12-31
NCT03420963	Ex-Vivo Expanded Allogeneic NK Cells For The Treatment Of Pediatric Solid Tumors	https://ClinicalTrials.gov/show/NCT03420963	Recruiting	M.D. Anderson Cancer Center	2022-12-01
NCT03267914	Impact of Compliance With Fluoride Use on Caries Incidence After Cancer Therapy	https://ClinicalTrials.gov/show/NCT03267914	Recruiting	A.T. Still University of Health Sciences	2020-02-28
NCT03212079	Physical Activities by Technology Help (PATH)	https://ClinicalTrials.gov/show/NCT03212079	Completed	Johns Hopkins University	2018-03-15
NCT03096808	Adaptive Radiotherapy for Head and Neck Cancer	https://ClinicalTrials.gov/show/NCT03096808	Active, not recruiting	Memorial Sloan Kettering Cancer Center	2021-03-15
NCT03082534	Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT03082534	Recruiting	University of California, San Diego	2019-12-30
NCT03067610	Involved Field Elective Volume De-Intensification Radiation Therapy for Head and Neck Cancer	https://ClinicalTrials.gov/show/NCT03067610	Active, not recruiting	University of Texas Southwestern Medical Center	2021-12-29
NCT03017053	The Optimal Neck Treatments Strategy of Early Oral Cancer Based on Adverse Pathological Factor	https://ClinicalTrials.gov/show/NCT03017053	Recruiting	Shanghai Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University	2025-07-31
NCT03010813	A Novel Robotic System for Single Port and Natural Orifice Transluminal Endoscopic Surgery	https://ClinicalTrials.gov/show/NCT03010813	Completed	Chinese University of Hong Kong	2017-10-31
NCT02981862	CaptHPV : Validation of the Method “CaptHPV” for the Diagnosis of Human Papillomavirus Associated Infiltrating Carcinomas	https://ClinicalTrials.gov/show/NCT02981862	Completed	Institut de Cancérologie de Lorraine	2018-06-12
NCT02946671	Study of Pre-operative Combination Therapy With Mogamulizumab and Nivolumab Against Solid Cancer Patients	https://ClinicalTrials.gov/show/NCT02946671	Completed	Osaka University	2020-03-31
NCT02921724	Participatory Research for Fine-tuning of a 2.0 System to Optimise Home Management of Oral Cancer Therapies.	https://ClinicalTrials.gov/show/NCT02921724	Active, not recruiting	Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori	2020-05-31
NCT02823847	Non Invasive Oral Cancer Screening Among HIV Infected Individuals	https://ClinicalTrials.gov/show/NCT02823847	Active, not recruiting	M.D. Anderson Cancer Center	2020-07-31
NCT02734537	Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery	https://ClinicalTrials.gov/show/NCT02734537	Recruiting	Eastern Cooperative Oncology Group	2022-05-01
NCT02608879	Oral Care Protocol for the Management of Chemotherapy and Radiation Therapy-Induced Oral Mucositis	https://ClinicalTrials.gov/show/NCT02608879	Completed	NYU Langone Health	2015-09-30
NCT02604121	Cytological Screening for Early Diagnosis of Precancerous or Cancerous Lesions of Oral Cavity	https://ClinicalTrials.gov/show/NCT02604121	Completed	University Hospital, Toulouse	2019-02-28
NCT02586207	Pembrolizumab in Combination With CRT for LA-SCCHN	https://ClinicalTrials.gov/show/NCT02586207	Active, not recruiting	Sanford Health	2020-06-30
NCT02584270	Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue	https://ClinicalTrials.gov/show/NCT02584270	Recruiting	University of Michigan	2022-01-31
NCT03021993	Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer	https://ClinicalTrials.gov/show/NCT03021993	Recruiting	Medical University of South Carolina	2020-12-31
NCT02478138	Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging	https://ClinicalTrials.gov/show/NCT02478138	Recruiting	University Health Network, Toronto	2020-12-31
NCT02412241	Establishing Lymphedema and Fibrosis Measures in Oral Cancer Patients	https://ClinicalTrials.gov/show/NCT02412241	Active, not recruiting	Vanderbilt-Ingram Cancer Center	2020-02-29
NCT02290145	Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage	https://ClinicalTrials.gov/show/NCT02290145	Recruiting	Shanghai Jiao Tong University School of Medicine	2023-07-31
NCT02285543	A Phase II Trial of TPF Induction Chemotherapy in cN2 OSCC Patients	https://ClinicalTrials.gov/show/NCT02285543	Recruiting	Shanghai Jiao Tong University School of Medicine	2023-12-31
NCT03385720	Submandibular Gland Preservation in Neck Dissection	https://ClinicalTrials.gov/show/NCT03385720	Recruiting	Peking University	2020-12-31
NCT02043184	Improving Adherence to Oral Cancer Agents and Self Care of Symptoms Using an IVR	https://ClinicalTrials.gov/show/NCT02043184	Completed	Michigan State University	2016-07-31
NCT03174275	Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT03174275	Recruiting	UNC Lineberger Comprehensive Cancer Center	2021-09-01
NCT03258554	Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin	https://ClinicalTrials.gov/show/NCT03258554	Recruiting	National Cancer Institute (NCI)	2025-12-31
NCT01958762	Screening for Cancers in the Oral CAvity	https://ClinicalTrials.gov/show/NCT01958762	Recruiting	Centre Hospitalier Universitaire, Amiens	2018-12-31
NCT01816841	Direct Visual Fluorescence in Finding Oral Cancer in High-Risk Patients and Patients Undergoing Routine Dental Care	https://ClinicalTrials.gov/show/NCT01816841	Completed	Ohio State University Comprehensive Cancer Center	2016-10-03
NCT01806675	18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy	https://ClinicalTrials.gov/show/NCT01806675	Completed	Stanford University	2016-12-07
NCT01790204	A Study of the Effects of PEITC on Oral Cells With Mutant p53	https://ClinicalTrials.gov/show/NCT01790204	Completed	Georgetown University	2014-04-30
NCT01733797	Trismus Trial of Therabite vs Wooden Spatula in Head and Neck Cancer Patients	https://ClinicalTrials.gov/show/NCT01733797	Completed	The Christie NHS Foundation Trust	2015-08-31
NCT01695122	Valproic Acid and Platinum-based Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT01695122	Completed	Instituto do Cancer do Estado de São Paulo	2014-11-30
NCT01649349	The Feasibility Study of Dual-Section Nasogastric Tube	https://ClinicalTrials.gov/show/NCT01649349	Completed	Changhua Christian Hospital	2012-06-30
NCT01604759	Polarized Reflectance Spectroscopy for Oral Lesions	https://ClinicalTrials.gov/show/NCT01604759	Completed	British Columbia Cancer Agency	2015-12-31
NCT01553851	GSK1120212 in Surgically Resectable Oral Cavity Squamous Cell Cancer	https://ClinicalTrials.gov/show/NCT01553851	Completed	Washington University School of Medicine	2015-06-30
NCT01514552	The Use of Functional Confections in Promoting Oral Health	https://ClinicalTrials.gov/show/NCT01514552	Active, not recruiting	Ohio State University	2020-12-31
NCT01504932	Freeze-Dried Black Raspberries in Preventing Oral Cancer Recurrence in High At-Risk Appalachian Patients Oral Cancer Survivors	https://ClinicalTrials.gov/show/NCT01504932	Completed	Ohio State University Comprehensive Cancer Center	2015-04-22
NCT01473784	Transoral Robotic Surgery in Treating Patients With Benign or Malignant Tumors of the Head and Neck	https://ClinicalTrials.gov/show/NCT01473784	Recruiting	Ohio State University Comprehensive Cancer Center	2020-12-31
NCT01469429	Phase 1b Food Based Modulation of Biomarkers in Human Tissues at High-Risk for Oral Cancer.	https://ClinicalTrials.gov/show/NCT01469429	Completed	Ohio State University Comprehensive Cancer Center	2014-09-17
NCT01445405	Radiation Therapy and Bortezomib and Cetuximab With or Without Cisplatin to Treat Head and Neck Cancer	https://ClinicalTrials.gov/show/NCT01445405	Completed	National Institutes of Health Clinical Center (CC)	2010-08-27
NCT01440270	Neo-adjuvant Erbitux-based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer	https://ClinicalTrials.gov/show/NCT01440270	Completed	Shanghai Jiao Tong University School of Medicine	2014-10-31
NCT01434394	Neoadjuvant Erbitux Based Chemotherapy for Locally Advanced Oral/Oropharyngeal Cancer	https://ClinicalTrials.gov/show/NCT01434394	Completed	Shanghai Jiao Tong University School of Medicine	2014-10-31
NCT01424358	Web-based Education on Oral Cancer for Primary Care Physicians in Ohio	https://ClinicalTrials.gov/show/NCT01424358	Completed	Creighton University	2013-09-30
NCT01418118	Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery	https://ClinicalTrials.gov/show/NCT01418118	Completed	Oxford University Hospitals NHS Trust	2010-02-28
NCT01365169	Post-op Wellness Program for Pancreatic Cancer Patients That Uses Patient Feedback and Real-time Provider Monitoring	https://ClinicalTrials.gov/show/NCT01365169	Recruiting	M.D. Anderson Cancer Center	2025-02-25
NCT01351532	Behavior Change on Oral Cancer Patients After a Localized Behavior Change Model Intervention	https://ClinicalTrials.gov/show/NCT01351532	Completed	China Medical University Hospital	2011-10-31
NCT04330781	Radiotherapy of Head and Neck Cancer Using an Intraoral Stent	https://ClinicalTrials.gov/show/NCT04330781	Recruiting	Oslo University Hospital	2022-12-31
NCT04265430	Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors	https://ClinicalTrials.gov/show/NCT04265430	Recruiting	M.D. Anderson Cancer Center	2021-09-30
NCT04214912	Personalized Survivor Care Plan for Oral Cancer Patients-Effects on Physical-Psychological Functions and Return-to-Work	https://ClinicalTrials.gov/show/NCT04214912	Recruiting	National Taiwan University Hospital	2020-07-31
NCT04126226	Quality of Life in Patients Treated for Tongue and/or Jaw Neoplasia Before and After Speech Therapy	https://ClinicalTrials.gov/show/NCT04126226	Completed	Hospital de Clinicas de Porto Alegre	2019-07-31
NCT04049968	Using an APP in Post Oral Cancer Surgery to Affect Patients’ Needs and Quality of Life.	https://ClinicalTrials.gov/show/NCT04049968	Completed	Far Eastern Memorial Hospital	2017-12-31
NCT03993353	Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer	https://ClinicalTrials.gov/show/NCT03993353	Recruiting	University of California, San Diego	2022-12-31
NCT03934294	Acupuncture Effect on Digestion in Critically Ill Post-Operative Oral and Hypo-pharyngeal Cancer Patients	https://ClinicalTrials.gov/show/NCT03934294	Recruiting	China Medical University Hospital	2021-05-25
NCT03923998	Adjuvant ChemoRadiotherapy Prior to Surgery in Stage IVa Oral Cancers	https://ClinicalTrials.gov/show/NCT03923998	Completed	Indrayani Hospital and Cancer Institute	2019-03-15
NCT03923881	MSOT Using Cetuximab-800CW for Detection of Cervical Lymph Node Metastases	https://ClinicalTrials.gov/show/NCT03923881	Recruiting	University Medical Center Groningen	2020-09-30
NCT03875118	Effects of Mouth-opening Training on the Maximum Interincisal Opening	https://ClinicalTrials.gov/show/NCT03875118	Completed	National Taipei University of Nursing and Health Sciences	2014-03-31
NCT03858712	EHR-embedded OCDT in Breast or GI Cancer	https://ClinicalTrials.gov/show/NCT03858712	Recruiting	Dana-Farber Cancer Institute	2021-03-31
NCT03853655	Adjuvant Radiotherapy in Early Stage Oral Cancers	https://ClinicalTrials.gov/show/NCT03853655	Recruiting	Tata Memorial Hospital	2022-08-01
NCT03843515	Neoadjuvant Nivolumab for Oral Cancer Combined With FDG and Anti-PD-L1 PET/CT Imaging for Response Prediction	https://ClinicalTrials.gov/show/NCT03843515	Recruiting	VU University Medical Center	2021-04-30
NCT01269190	Wide-Field and High Resolution In Vivo Imaging in Visualizing Lesions in Patients With Oral Neoplasia Undergoing Surgery	https://ClinicalTrials.gov/show/NCT01269190	Recruiting	M.D. Anderson Cancer Center	2020-12-31
NCT03749460	Nivolumab and Ipilimumab and Stereotactic Body Radiation Therapy in Treating Patients With Salivary Gland Cancers	https://ClinicalTrials.gov/show/NCT03749460	Recruiting	University of Washington	2022-12-22
NCT03737734	Alpha Radiation Emitters Device for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia (DaRT)	https://ClinicalTrials.gov/show/NCT03737734	Recruiting	Alpha Tau Medical LTD.	2020-12-31
NCT03685409	Cancer Chemoprevention by Metformin Hydrochloride in Oral Potentially Malignant Lesions	https://ClinicalTrials.gov/show/NCT03685409	Recruiting	Cairo University	2019-09-30
NCT03684707	Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions	https://ClinicalTrials.gov/show/NCT03684707	Recruiting	Ain Shams University	2019-06-15
NCT03653039	Comparison Between a Standard Tube and the Ultra-thin Tritube for Intubation of the Trachea and for Maintaining Access to the Trachea After Anaesthesia, in Patients With an Expected Difficult Direct Laryngoscopy	https://ClinicalTrials.gov/show/NCT03653039	Recruiting	Rigshospitalet, Denmark	2019-03-31
NCT03638622	Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral Cancer Cancer.	https://ClinicalTrials.gov/show/NCT03638622	Completed	Massachusetts General Hospital	2019-08-31
NCT03604939	Improving Access to Control of Diseases for Women	https://ClinicalTrials.gov/show/NCT03604939	Completed	International Agency for Research on Cancer	2018-07-01
NCT03602079	Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene	https://ClinicalTrials.gov/show/NCT03602079	Recruiting	Klus Pharma Inc.	2020-10-31
NCT03575598	Sitravatinib (MGCD516) and Nivolumab in Oral Cavity Cancer Window Opportunity Study	https://ClinicalTrials.gov/show/NCT03575598	Recruiting	University Health Network, Toronto	2020-08-30
NCT03545100	Rehabilitation Outcomes of Shoulder Function in Oral Cancer Survivors Cancer Survivors	https://ClinicalTrials.gov/show/NCT03545100	Recruiting	Chang Gung Memorial Hospital	2020-02-29
NCT01254617	Lenalidomide and Cetuximab in Treating Patients With Advanced Colorectal Cancer or Head and Neck Cancer	https://ClinicalTrials.gov/show/NCT01254617	Completed	National Cancer Institute (NCI)	2014-01-29
NCT01195922	Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT01195922	Completed	National Institutes of Health Clinical Center (CC)	2015-06-30
NCT01192204	Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention	https://ClinicalTrials.gov/show/NCT01192204	Completed	Ohio State University	2014-02-28
NCT01116843	Study to Assess Biomarkers in Patients With Resectable Oral Cavity Cancer Randomized to Receive Preoperative Treatment	https://ClinicalTrials.gov/show/NCT01116843	Completed	University Health Network, Toronto	2012-02-29
NCT01108042	TPF-Induction Chemotherapy of Oropharyngeal and Cavity of the Mouth Cancer	https://ClinicalTrials.gov/show/NCT01108042	Completed	University of Jena	2016-01-31
NCT00953849	Vitamin D Plus Celecoxib Therapy to Stimulate Intratumoral Immune Reactivity	https://ClinicalTrials.gov/show/NCT00953849	Completed	VA Office of Research and Development	2015-12-31
NCT00933387	A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT00933387	Completed	National Health Research Institutes, Taiwan	2011-07-31
NCT00847717	Trial of IIb Preserving Neck Dissection	https://ClinicalTrials.gov/show/NCT00847717	Completed	Banaras Hindu University	2009-08-31
NCT02581137	Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion	https://ClinicalTrials.gov/show/NCT02581137	Active, not recruiting	National Cancer Institute (NCI)	2017-10-12
NCT03529422	Durvalumab With Radiotherapy for Adjuvant Treatment of Intermediate Risk SCCHN	https://ClinicalTrials.gov/show/NCT03529422	Recruiting	UNC Lineberger Comprehensive Cancer Center	2021-02-15
NCT04393506	Inductive Camrelizumab and Apatinib for Patients With Locally Advanced and Resectable Oral Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT04393506	Recruiting	Shanghai Jiao Tong University School of Medicine	2020-12-31
NCT00721799	F-18 Fluorothymidine PET Imaging for Early Evaluation of Response to Therapy in Head & Neck Cancer Patients	https://ClinicalTrials.gov/show/NCT00721799	Completed	University of Iowa	2014-12-31
NCT00542373	Widefield Fluorescence and Reflectance Imaging Systems and Oral Tissue Samples in Monitoring Participants at Risk for Developing Oral Cancer	https://ClinicalTrials.gov/show/NCT00542373	Active, not recruiting	M.D. Anderson Cancer Center	2020-08-31
NCT00507182	Spectroscopy for Diagnostic Assessment of Oral Mucosal Lesions	https://ClinicalTrials.gov/show/NCT00507182	Completed	M.D. Anderson Cancer Center	2018-01-12
NCT00402779	Erlotinib Prevention of Oral Cancer (EPOC)	https://ClinicalTrials.gov/show/NCT00402779	Completed	M.D. Anderson Cancer Center	2018-06-04
NCT00359645	Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population	https://ClinicalTrials.gov/show/NCT00359645	Completed	Gustave Roussy, Cancer Campus, Grand Paris	2015-12-18
NCT00330382	Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia	https://ClinicalTrials.gov/show/NCT00330382	Completed	National Cancer Institute (NCI)	2010-07-31
NCT00162708	Very Intense Radiotherapy-Chemotherapy Regimen in Advanced HNSCC	https://ClinicalTrials.gov/show/NCT00162708	Completed	Gustave Roussy, Cancer Campus, Grand Paris	NA
NCT00158678	IMRT Plus Cisplatin Versus Conventional Radiotherapy Plus Cisplatin in Stage III-IV HNSCC	https://ClinicalTrials.gov/show/NCT00158678	Completed	Groupe Oncologie Radiotherapie Tete et Cou	2020-03-22
NCT00158652	Accelerated Radiotherapy and Concomitant Chemo-radiotherapy in HNSCC	https://ClinicalTrials.gov/show/NCT00158652	Completed	Groupe Oncologie Radiotherapie Tete et Cou	2011-03-31
NCT00064103	Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx	https://ClinicalTrials.gov/show/NCT00064103	Completed	National Cancer Institute (NCI)	2007-08-31
NCT00028405	Photodynamic Therapy System for Patients With Refractory/Unresponsive Solid Tumors	https://ClinicalTrials.gov/show/NCT00028405	Completed	Light Sciences LLC	NA
NCT00750503	Workplace Tobacco Cessation And Oral Cancer Screening Study	https://ClinicalTrials.gov/show/NCT00750503	Completed	Tata Memorial Hospital	2008-06-30

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03304132	The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer	https://ClinicalTrials.gov/show/NCT03304132	Completed	NYU Langone Health	2010-12-01
NCT03206242	Rehabilitation Outcomes in Head and Neck Survivors	https://ClinicalTrials.gov/show/NCT03206242	Completed	Chang Gung Memorial Hospital	2016-06-30
NCT02663583	Intensity-Modulated Proton Therapy (IMPT) or TransOral Robotic Surgery (TORS) for the Treatment of Low-Risk Oropharynx Squamous Cell	https://ClinicalTrials.gov/show/NCT02663583	Recruiting	M.D. Anderson Cancer Center	2020-12-31
NCT02648789	Validation of DNA Methylation Biomarkers for Oral Cancer Detection	https://ClinicalTrials.gov/show/NCT02648789	Completed	Taipei Veterans General Hospital, Taiwan	2017-05-31
NCT00341497	Biomarkers for Oral Cancer	https://ClinicalTrials.gov/show/NCT00341497	Completed	National Institutes of Health Clinical Center (CC)	NA
NCT02507141	Reflectance Confocal Microscopy of Oral Cancers in Vivo: a Preliminary Trial Comparing Intra-oral Imaging With Pathology	https://ClinicalTrials.gov/show/NCT02507141	Recruiting	Memorial Sloan Kettering Cancer Center	2020-07-31
NCT02323672	Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions	https://ClinicalTrials.gov/show/NCT02323672	Completed	Cairo University	2014-09-30
NCT02048631	Analysis Of Sensory Recovery Of Donor Size And Quality Life In Oral Cancer Patients	https://ClinicalTrials.gov/show/NCT02048631	Completed	Kaohsiung Medical University Chung-Ho Memorial Hospital	2014-02-28
NCT01945697	Validation of DNA Methylation Biomarkers for Oral Cancer Detection	https://ClinicalTrials.gov/show/NCT01945697	Completed	National Taiwan University Hospital	2014-09-30
NCT01817140	Assessment of Mandibular Bone Invasion With MRI Using SWIFT	https://ClinicalTrials.gov/show/NCT01817140	Completed	University of Minnesota	2017-09-01
NCT01531881	Autofluorescence Detection of Oral Malignancies and Database and Biospecimen Collection to Identify Biomarkers of Head and Neck Tumor Progression	https://ClinicalTrials.gov/show/NCT01531881	Active, not recruiting	Roswell Park Cancer Institute	2014-01-31
NCT04267419	Malondialdehyde and Nitrous Oxide as Salivary Biomarkers for Different Oral Lesions	https://ClinicalTrials.gov/show/NCT04267419	Completed	Beni-Suef University	2019-12-15
NCT04163029	Oral Care Study of Postoperative Infections	https://ClinicalTrials.gov/show/NCT04163029	Recruiting	University of Liege	2021-12-01
NCT04041141	Oral Stent Device for Radiation Treatments of Oral Cancers	https://ClinicalTrials.gov/show/NCT04041141	Recruiting	Indiana University	2020-09-30
NCT03905005	Jaw Reconstruction With Printed Titanium and Free Tissue Transfer	https://ClinicalTrials.gov/show/NCT03905005	Recruiting	University of South Wales	2020-09-30
NCT03877159	Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	https://ClinicalTrials.gov/show/NCT03877159	Recruiting	Guy’s and St Thomas’ NHS Foundation Trust	2020-01-30
NCT03862066	Memory Phenotype in Oral Cancer	https://ClinicalTrials.gov/show/NCT03862066	Recruiting	Medical University of South Carolina	2020-12-01
NCT03776578	Oral Cancer With Wide Excision and Free Flap Reconstruction	https://ClinicalTrials.gov/show/NCT03776578	Recruiting	National Taiwan University Hospital	2021-06-30
NCT03686020	Sensitivity and Specificity of Serum and Salivary CYFRA21-1 in the Detection of Malignant Transformation in Oral Potentially Malignant Mucosal Lesions (Diagnostic Accuracy Study)	https://ClinicalTrials.gov/show/NCT03686020	Recruiting	Cairo University	2019-10-31
NCT03555721	CytID Analysis of Oral Lesions	https://ClinicalTrials.gov/show/NCT03555721	Recruiting	The University of Texas Health Science Center, Houston	2019-11-01
NCT03529604	Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients	https://ClinicalTrials.gov/show/NCT03529604	Active, not recruiting	University of Zagreb	2020-04-01
NCT01104714	Pharmacogenetic Response to Chemotherapy Induction for ORL Cancers	https://ClinicalTrials.gov/show/NCT01104714	Completed	Centre Hospitalier Universitaire de NÄ«mes	2014-07-31
NCT01084733	Nicotine Levels With Response Rates to Radiation Alone or With Chemo In Head & Neck Cancer	https://ClinicalTrials.gov/show/NCT01084733	Active, not recruiting	University of Kentucky	2021-02-28
NCT01039272	Epstein-Barr Detection in Oral Cancer	https://ClinicalTrials.gov/show/NCT01039272	Completed	UPECLIN HC FM Botucatu Unesp	2008-04-30
NCT01862809	Cigarette Smoking and Oral Microbiota	https://ClinicalTrials.gov/show/NCT01862809	Completed	National Institutes of Health Clinical Center (CC)	2014-12-05
NCT00867464	Extended Follow-Up of Young Women in Costa Rica Who Received Vaccination Against Human Papillomavirus Types 16 and 18 and Unvaccinated Controls	https://ClinicalTrials.gov/show/NCT00867464	Active, not recruiting	National Institutes of Health Clinical Center (CC)	NA
NCT00526851	Oral Cancer Screening Among Nursing Home Dentists in Ohio	https://ClinicalTrials.gov/show/NCT00526851	Completed	Case Comprehensive Cancer Center	2008-01-31
NCT00502580	Evaluation of a Multispectral Vision Enhancement System for Assessment of Oral Mucosal Lesions	https://ClinicalTrials.gov/show/NCT00502580	Completed	M.D. Anderson Cancer Center	2008-03-31
NCT00502125	In Vivo Confocal Imaging of Oral Mucosa	https://ClinicalTrials.gov/show/NCT00502125	Completed	M.D. Anderson Cancer Center	2009-09-30
NCT00439205	Oral Margin Spectroscopy Detection Using Optical Spectroscopy	https://ClinicalTrials.gov/show/NCT00439205	Completed	M.D. Anderson Cancer Center	2017-10-10
NCT00412490	Smoking Status and Body Image in Oral Cancer Patients	https://ClinicalTrials.gov/show/NCT00412490	Completed	M.D. Anderson Cancer Center	2014-12-31
NCT00364715	Study the Expression of Annexin A1 and Its Potential Usage as a Prognostic Marker in Oral Cancer	https://ClinicalTrials.gov/show/NCT00364715	Completed	National Taiwan University Hospital	NA
NCT00200837	Ethnopharmacological Studies in Oral Medicine	https://ClinicalTrials.gov/show/NCT00200837	Completed	National Center for Complementary and Integrative Health (NCCIH)	NA
NCT00186433	A Longitudinal Study of Plasma EBV DNA in Nasopharyngeal Carcinoma From Both Endemic and Non-Endemic Patient Populations	https://ClinicalTrials.gov/show/NCT00186433	Completed	Stanford University	2013-06-30
NCT00011492	Patient Evaluation for Head and Neck Surgery Branch Studies	https://ClinicalTrials.gov/show/NCT00011492	Recruiting	National Institutes of Health Clinical Center (CC)	NA

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03202810	Innovative Approach to Triage Oral Precancer	https://ClinicalTrials.gov/show/NCT03202810	Recruiting	British Columbia Cancer Agency	2021-11-14
NCT02012699	Integrated Cancer Repository for Cancer Research	https://ClinicalTrials.gov/show/NCT02012699	Recruiting	University of Nebraska	2099-12-31
NCT04081038	Dental Hygienists and Dentists as Providers of Oral Mucosa Screening and Brush Biopsies	https://ClinicalTrials.gov/show/NCT04081038	Recruiting	Dalarna County Council, Sweden	2020-12-31